AustralieFrV1, Main, Exploration, bibRecord, 007741

Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy

Identifieur interne : 007741 ( Main/Exploration ); précédent : 007740; suivant : 007742

Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy

Auteurs : Emmanuelle Bouzigon [France] ; Paola Forabosco [Royaume-Uni, Italie] ; Gerard H. Koppelman [Pays-Bas] ; William Ocm Cookson [Royaume-Uni] ; Marie-Hélène Dizier [France] ; David L. Duffy [Australie] ; David M. Evans [Royaume-Uni] ; Manuel Ar Ferreira [Australie] ; Juha Kere [Suède] ; Tarja Laitinen [Finlande] ; Giovanni Malerba [Italie] ; Deborah A. Meyers [États-Unis] ; Miriam Moffatt [Royaume-Uni] ; Nicholas G. Martin [Australie] ; Mandy Y. Ng [Royaume-Uni] ; Pier Franco Pignatti [Italie] ; Mathias Wjst [Allemagne, Italie] ; Francine Kauffmann [France] ; Florence Demenais [France] ; Cathryn M. Lewis [Royaume-Uni]

Source :

European journal of human genetics [ 1018-4813 ] ; 2010.

RBID : Pascal:10-0271543

Descripteurs français

Pascal (Inist)
- Asthme, Atopie, Métaanalyse, Génome, Liaison génétique, Pathogénie, Déterminisme génétique, Carte génétique, Allergie, Immunopathologie, Génétique.
Wicri :
- topic : Allergie, Génétique.

English descriptors

KwdEn :
- Allergy, Asthma, Atopy, Genetic determinism, Genetic linkage, Genetic mapping, Genetics, Genome, Immunopathology, Metaanalysis, Pathogenesis.

Abstract

Asthma is caused by a heterogeneous combination of environmental and genetic factors. In the context of GA2LEN (Global Allergy and Asthma European Network), we carried out meta-analyses of almost all genome-wide linkage screens conducted to date in 20 independent populations from different ethnic origins (≥3024 families with ≥ 10027 subjects) for asthma, atopic asthma, bronchial hyper-responsiveness and five atopy-related traits (total immunoglobulin E level, positive skin test response (SPT) to at least one allergen or to House Dust Mite, quantitative score of SPT (SPTQ) and eosinophils (EOS)). We used the genome scan meta-analysis method to assess evidence for linkage within bins of traditionally 30-cM width, and explored the manner in which these results were affected by bin definition. Meta-analyses were conducted in all studies and repeated in families of European ancestry. Genome-wide evidence for linkage was detected for asthma in two regions (2p21-p14 and 6p21) in European families ascertained through two asthmatic sibs. With regard to atopy phenotypes, four regions reached genome-wide significance: 3p25.3-q24 in all families for SPT and three other regions in European families (2q32-q34 for EOS, 5q23-q33 for SPTQ and 17q12-q24 for SPT). Tests of heterogeneity showed consistent evidence of linkage of SPTQ to 3p11-3q21, whereas between-study heterogeneity was detected for asthma in 2p22-p13 and 6p21, and for atopic asthma in 1q23-q25. This large-scale meta-analysis provides an important resource of information that can be used to prioritize further fine-mapping studies and also be integrated with genome-wide association studies to increase power and better interpret the outcomes of these studies.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987334

Affiliations:

Allemagne, Australie, Finlande, France, Italie, Pays-Bas, Royaume-Uni, Suède, États-Unis
Angleterre, Grand Londres, Groningue (province), Svealand, Uusimaa, Île-de-France
Groningue, Helsinki, Londres, Paris, Stockholm
Université d'Helsinki

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy</title>
<author><name sortKey="Bouzigon, Emmanuelle" sort="Bouzigon, Emmanuelle" uniqKey="Bouzigon E" first="Emmanuelle" last="Bouzigon">Emmanuelle Bouzigon</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U946</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universté Paris Diderot, Paris 7, Institut Universitaire d'Hématologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Foundation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH)</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Forabosco, Paola" sort="Forabosco, Paola" uniqKey="Forabosco P" first="Paola" last="Forabosco">Paola Forabosco</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>King's College London, Department of Medical and Molecular Genetics</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Istituto di Genetica delle Popolazioni-CNR</s1>
<s2>Alghero</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Istituto di Genetica delle Popolazioni-CNR</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen</s1>
<s2>Groningen</s2>
<s3>NLD</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cookson, William Ocm" sort="Cookson, William Ocm" uniqKey="Cookson W" first="William Ocm" last="Cookson">William Ocm Cookson</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>National Heart Lung Institute, Imperial College</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dizier, Marie Helene" sort="Dizier, Marie Helene" uniqKey="Dizier M" first="Marie-Hélène" last="Dizier">Marie-Hélène Dizier</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, U535</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>U535</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Univ Paris-Sud, IFR69</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>IFR69</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Duffy, David L" sort="Duffy, David L" uniqKey="Duffy D" first="David L." last="Duffy">David L. Duffy</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Queensland Institute of Medical Research, Royal Brisbane Hospital</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Social Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ferreira, Manuel Ar" sort="Ferreira, Manuel Ar" uniqKey="Ferreira M" first="Manuel Ar" last="Ferreira">Manuel Ar Ferreira</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Queensland Institute of Medical Research, Royal Brisbane Hospital</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kere, Juha" sort="Kere, Juha" uniqKey="Kere J" first="Juha" last="Kere">Juha Kere</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Biosciences and Nutrition, Karolinska Institute</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Laitinen, Tarja" sort="Laitinen, Tarja" uniqKey="Laitinen T" first="Tarja" last="Laitinen">Tarja Laitinen</name>
<affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Departments of Pulmonary Medicine and Medical Genetics, University of Helsinki</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
<author><name sortKey="Malerba, Giovanni" sort="Malerba, Giovanni" uniqKey="Malerba G" first="Giovanni" last="Malerba">Giovanni Malerba</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Section of Biology and Genetics, Department of Mother and Child, and Biology-Genetics, University of Verona</s1>
<s2>Verona</s2>
<s3>ITA</s3>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Verona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meyers, Deborah A" sort="Meyers, Deborah A" uniqKey="Meyers D" first="Deborah A." last="Meyers">Deborah A. Meyers</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Center for Human Genomics, Wake Forest University</s1>
<s2>Winston Salem, NC</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Winston Salem, NC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moffatt, Miriam" sort="Moffatt, Miriam" uniqKey="Moffatt M" first="Miriam" last="Moffatt">Miriam Moffatt</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>National Heart Lung Institute, Imperial College</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Queensland Institute of Medical Research, Royal Brisbane Hospital</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ng, Mandy Y" sort="Ng, Mandy Y" uniqKey="Ng M" first="Mandy Y." last="Ng">Mandy Y. Ng</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>King's College London, MRC SGDP Centre, Institute of Psychiatry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>15 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Franco Pignatti, Pier" sort="Franco Pignatti, Pier" uniqKey="Franco Pignatti P" first="Pier" last="Franco Pignatti">Pier Franco Pignatti</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Section of Biology and Genetics, Department of Mother and Child, and Biology-Genetics, University of Verona</s1>
<s2>Verona</s2>
<s3>ITA</s3>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Verona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wjst, Mathias" sort="Wjst, Mathias" uniqKey="Wjst M" first="Mathias" last="Wjst">Mathias Wjst</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Institute of Experimental Pneumology, Helmholtz Zentrum München, German Research Center for Environmental Health</s1>
<s2>Neuherberg</s2>
<s3>DEU</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>German Research Center for Environmental Health</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Institute of Genetic Medicine, EURAC research</s1>
<s2>Bozen</s2>
<s3>ITA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bozen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kauffmann, Francine" sort="Kauffmann, Francine" uniqKey="Kauffmann F" first="Francine" last="Kauffmann">Francine Kauffmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Univ Paris-Sud, IFR69</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>IFR69</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>INSERM, U780</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>U780</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U946</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universté Paris Diderot, Paris 7, Institut Universitaire d'Hématologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Foundation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH)</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M." last="Lewis">Cathryn M. Lewis</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>King's College London, Department of Medical and Molecular Genetics</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>King's College London, MRC SGDP Centre, Institute of Psychiatry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>15 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0271543</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0271543 INIST</idno>
<idno type="RBID">Pascal:10-0271543</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002643</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003943</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002267</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002267</idno>
<idno type="wicri:doubleKey">1018-4813:2010:Bouzigon E:meta:analysis:of</idno>
<idno type="wicri:Area/Main/Merge">007D35</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987334</idno>
<idno type="RBID">PMC:2987334</idno>
<idno type="wicri:Area/Pmc/Corpus">000054</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000054</idno>
<idno type="wicri:Area/Pmc/Curation">000054</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000054</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002536</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002536</idno>
<idno type="wicri:Area/Ncbi/Merge">000705</idno>
<idno type="wicri:Area/Ncbi/Curation">000705</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000705</idno>
<idno type="wicri:doubleKey">1018-4813:2010:Bouzigon E:meta:analysis:of</idno>
<idno type="wicri:Area/Main/Merge">007431</idno>
<idno type="wicri:Area/Main/Curation">007741</idno>
<idno type="wicri:Area/Main/Exploration">007741</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy</title>
<author><name sortKey="Bouzigon, Emmanuelle" sort="Bouzigon, Emmanuelle" uniqKey="Bouzigon E" first="Emmanuelle" last="Bouzigon">Emmanuelle Bouzigon</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U946</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universté Paris Diderot, Paris 7, Institut Universitaire d'Hématologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Foundation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH)</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Forabosco, Paola" sort="Forabosco, Paola" uniqKey="Forabosco P" first="Paola" last="Forabosco">Paola Forabosco</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>King's College London, Department of Medical and Molecular Genetics</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Istituto di Genetica delle Popolazioni-CNR</s1>
<s2>Alghero</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Istituto di Genetica delle Popolazioni-CNR</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, University of Groningen</s1>
<s2>Groningen</s2>
<s3>NLD</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cookson, William Ocm" sort="Cookson, William Ocm" uniqKey="Cookson W" first="William Ocm" last="Cookson">William Ocm Cookson</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>National Heart Lung Institute, Imperial College</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dizier, Marie Helene" sort="Dizier, Marie Helene" uniqKey="Dizier M" first="Marie-Hélène" last="Dizier">Marie-Hélène Dizier</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM, U535</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>U535</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Univ Paris-Sud, IFR69</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>IFR69</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Duffy, David L" sort="Duffy, David L" uniqKey="Duffy D" first="David L." last="Duffy">David L. Duffy</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Queensland Institute of Medical Research, Royal Brisbane Hospital</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Social Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ferreira, Manuel Ar" sort="Ferreira, Manuel Ar" uniqKey="Ferreira M" first="Manuel Ar" last="Ferreira">Manuel Ar Ferreira</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Queensland Institute of Medical Research, Royal Brisbane Hospital</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kere, Juha" sort="Kere, Juha" uniqKey="Kere J" first="Juha" last="Kere">Juha Kere</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Biosciences and Nutrition, Karolinska Institute</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Laitinen, Tarja" sort="Laitinen, Tarja" uniqKey="Laitinen T" first="Tarja" last="Laitinen">Tarja Laitinen</name>
<affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Departments of Pulmonary Medicine and Medical Genetics, University of Helsinki</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
<author><name sortKey="Malerba, Giovanni" sort="Malerba, Giovanni" uniqKey="Malerba G" first="Giovanni" last="Malerba">Giovanni Malerba</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Section of Biology and Genetics, Department of Mother and Child, and Biology-Genetics, University of Verona</s1>
<s2>Verona</s2>
<s3>ITA</s3>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Verona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meyers, Deborah A" sort="Meyers, Deborah A" uniqKey="Meyers D" first="Deborah A." last="Meyers">Deborah A. Meyers</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Center for Human Genomics, Wake Forest University</s1>
<s2>Winston Salem, NC</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Winston Salem, NC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moffatt, Miriam" sort="Moffatt, Miriam" uniqKey="Moffatt M" first="Miriam" last="Moffatt">Miriam Moffatt</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>National Heart Lung Institute, Imperial College</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Queensland Institute of Medical Research, Royal Brisbane Hospital</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ng, Mandy Y" sort="Ng, Mandy Y" uniqKey="Ng M" first="Mandy Y." last="Ng">Mandy Y. Ng</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>King's College London, MRC SGDP Centre, Institute of Psychiatry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>15 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Franco Pignatti, Pier" sort="Franco Pignatti, Pier" uniqKey="Franco Pignatti P" first="Pier" last="Franco Pignatti">Pier Franco Pignatti</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Section of Biology and Genetics, Department of Mother and Child, and Biology-Genetics, University of Verona</s1>
<s2>Verona</s2>
<s3>ITA</s3>
<sZ>11 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Verona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wjst, Mathias" sort="Wjst, Mathias" uniqKey="Wjst M" first="Mathias" last="Wjst">Mathias Wjst</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Institute of Experimental Pneumology, Helmholtz Zentrum München, German Research Center for Environmental Health</s1>
<s2>Neuherberg</s2>
<s3>DEU</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>German Research Center for Environmental Health</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Institute of Genetic Medicine, EURAC research</s1>
<s2>Bozen</s2>
<s3>ITA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bozen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kauffmann, Francine" sort="Kauffmann, Francine" uniqKey="Kauffmann F" first="Francine" last="Kauffmann">Francine Kauffmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Univ Paris-Sud, IFR69</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>IFR69</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>INSERM, U780</s1>
<s2>Villejuif</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>U780</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U946</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Universté Paris Diderot, Paris 7, Institut Universitaire d'Hématologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Foundation Jean Dausset-Centre d'Etude du Polymorphisme Humain (CEPH)</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M." last="Lewis">Cathryn M. Lewis</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>King's College London, Department of Medical and Molecular Genetics</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>King's College London, MRC SGDP Centre, Institute of Psychiatry</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>15 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">European journal of human genetics</title>
<title level="j" type="abbreviated">Eur. j. hum. genet.</title>
<idno type="ISSN">1018-4813</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">European journal of human genetics</title>
<title level="j" type="abbreviated">Eur. j. hum. genet.</title>
<idno type="ISSN">1018-4813</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Allergy</term>
<term>Asthma</term>
<term>Atopy</term>
<term>Genetic determinism</term>
<term>Genetic linkage</term>
<term>Genetic mapping</term>
<term>Genetics</term>
<term>Genome</term>
<term>Immunopathology</term>
<term>Metaanalysis</term>
<term>Pathogenesis</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Asthme</term>
<term>Atopie</term>
<term>Métaanalyse</term>
<term>Génome</term>
<term>Liaison génétique</term>
<term>Pathogénie</term>
<term>Déterminisme génétique</term>
<term>Carte génétique</term>
<term>Allergie</term>
<term>Immunopathologie</term>
<term>Génétique</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Allergie</term>
<term>Génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Asthma is caused by a heterogeneous combination of environmental and genetic factors. In the context of GA2LEN (Global Allergy and Asthma European Network), we carried out meta-analyses of almost all genome-wide linkage screens conducted to date in 20 independent populations from different ethnic origins (≥3024 families with ≥ 10027 subjects) for asthma, atopic asthma, bronchial hyper-responsiveness and five atopy-related traits (total immunoglobulin E level, positive skin test response (SPT) to at least one allergen or to House Dust Mite, quantitative score of SPT (SPTQ) and eosinophils (EOS)). We used the genome scan meta-analysis method to assess evidence for linkage within bins of traditionally 30-cM width, and explored the manner in which these results were affected by bin definition. Meta-analyses were conducted in all studies and repeated in families of European ancestry. Genome-wide evidence for linkage was detected for asthma in two regions (2p21-p14 and 6p21) in European families ascertained through two asthmatic sibs. With regard to atopy phenotypes, four regions reached genome-wide significance: 3p25.3-q24 in all families for SPT and three other regions in European families (2q32-q34 for EOS, 5q23-q33 for SPTQ and 17q12-q24 for SPT). Tests of heterogeneity showed consistent evidence of linkage of SPTQ to 3p11-3q21, whereas between-study heterogeneity was detected for asthma in 2p22-p13 and 6p21, and for atopic asthma in 1q23-q25. This large-scale meta-analysis provides an important resource of information that can be used to prioritize further fine-mapping studies and also be integrated with genome-wide association studies to increase power and better interpret the outcomes of these studies.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Finlande</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Groningue (province)</li>
<li>Svealand</li>
<li>Uusimaa</li>
<li>Île-de-France</li>
</region>
<settlement><li>Groningue</li>
<li>Helsinki</li>
<li>Londres</li>
<li>Paris</li>
<li>Stockholm</li>
</settlement>
<orgName><li>Université d'Helsinki</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Bouzigon, Emmanuelle" sort="Bouzigon, Emmanuelle" uniqKey="Bouzigon E" first="Emmanuelle" last="Bouzigon">Emmanuelle Bouzigon</name>
</region>
<name sortKey="Bouzigon, Emmanuelle" sort="Bouzigon, Emmanuelle" uniqKey="Bouzigon E" first="Emmanuelle" last="Bouzigon">Emmanuelle Bouzigon</name>
<name sortKey="Bouzigon, Emmanuelle" sort="Bouzigon, Emmanuelle" uniqKey="Bouzigon E" first="Emmanuelle" last="Bouzigon">Emmanuelle Bouzigon</name>
<name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
<name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
<name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
<name sortKey="Dizier, Marie Helene" sort="Dizier, Marie Helene" uniqKey="Dizier M" first="Marie-Hélène" last="Dizier">Marie-Hélène Dizier</name>
<name sortKey="Dizier, Marie Helene" sort="Dizier, Marie Helene" uniqKey="Dizier M" first="Marie-Hélène" last="Dizier">Marie-Hélène Dizier</name>
<name sortKey="Kauffmann, Francine" sort="Kauffmann, Francine" uniqKey="Kauffmann F" first="Francine" last="Kauffmann">Francine Kauffmann</name>
<name sortKey="Kauffmann, Francine" sort="Kauffmann, Francine" uniqKey="Kauffmann F" first="Francine" last="Kauffmann">Francine Kauffmann</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Forabosco, Paola" sort="Forabosco, Paola" uniqKey="Forabosco P" first="Paola" last="Forabosco">Paola Forabosco</name>
</region>
<name sortKey="Cookson, William Ocm" sort="Cookson, William Ocm" uniqKey="Cookson W" first="William Ocm" last="Cookson">William Ocm Cookson</name>
<name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name>
<name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M." last="Lewis">Cathryn M. Lewis</name>
<name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M." last="Lewis">Cathryn M. Lewis</name>
<name sortKey="Moffatt, Miriam" sort="Moffatt, Miriam" uniqKey="Moffatt M" first="Miriam" last="Moffatt">Miriam Moffatt</name>
<name sortKey="Ng, Mandy Y" sort="Ng, Mandy Y" uniqKey="Ng M" first="Mandy Y." last="Ng">Mandy Y. Ng</name>
</country>
<country name="Italie"><noRegion><name sortKey="Forabosco, Paola" sort="Forabosco, Paola" uniqKey="Forabosco P" first="Paola" last="Forabosco">Paola Forabosco</name>
</noRegion>
<name sortKey="Franco Pignatti, Pier" sort="Franco Pignatti, Pier" uniqKey="Franco Pignatti P" first="Pier" last="Franco Pignatti">Pier Franco Pignatti</name>
<name sortKey="Malerba, Giovanni" sort="Malerba, Giovanni" uniqKey="Malerba G" first="Giovanni" last="Malerba">Giovanni Malerba</name>
<name sortKey="Wjst, Mathias" sort="Wjst, Mathias" uniqKey="Wjst M" first="Mathias" last="Wjst">Mathias Wjst</name>
</country>
<country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Koppelman, Gerard H" sort="Koppelman, Gerard H" uniqKey="Koppelman G" first="Gerard H." last="Koppelman">Gerard H. Koppelman</name>
</region>
</country>
<country name="Australie"><noRegion><name sortKey="Duffy, David L" sort="Duffy, David L" uniqKey="Duffy D" first="David L." last="Duffy">David L. Duffy</name>
</noRegion>
<name sortKey="Ferreira, Manuel Ar" sort="Ferreira, Manuel Ar" uniqKey="Ferreira M" first="Manuel Ar" last="Ferreira">Manuel Ar Ferreira</name>
<name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Kere, Juha" sort="Kere, Juha" uniqKey="Kere J" first="Juha" last="Kere">Juha Kere</name>
</region>
</country>
<country name="Finlande"><region name="Uusimaa"><name sortKey="Laitinen, Tarja" sort="Laitinen, Tarja" uniqKey="Laitinen T" first="Tarja" last="Laitinen">Tarja Laitinen</name>
</region>
</country>
<country name="États-Unis"><noRegion><name sortKey="Meyers, Deborah A" sort="Meyers, Deborah A" uniqKey="Meyers D" first="Deborah A." last="Meyers">Deborah A. Meyers</name>
</noRegion>
</country>
<country name="Allemagne"><noRegion><name sortKey="Wjst, Mathias" sort="Wjst, Mathias" uniqKey="Wjst M" first="Mathias" last="Wjst">Mathias Wjst</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007741 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007741 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:10-0271543
   |texte=   Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy

Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.